Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines...

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Detalles Bibliográficos
Autores principales: Said, Thenaa K, Moraes, Ricardo CB, Sinha, Raghu, Medina, Daniel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13923/
https://www.ncbi.nlm.nih.gov/pubmed/11250759
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author Said, Thenaa K
Moraes, Ricardo CB
Sinha, Raghu
Medina, Daniel
author_facet Said, Thenaa K
Moraes, Ricardo CB
Sinha, Raghu
Medina, Daniel
author_sort Said, Thenaa K
collection PubMed
description The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.
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spelling pubmed-139232001-02-27 Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth Said, Thenaa K Moraes, Ricardo CB Sinha, Raghu Medina, Daniel Breast Cancer Res Primary Research The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines. BioMed Central 2001 2000-12-22 /pmc/articles/PMC13923/ /pubmed/11250759 Text en Copyright © 2000 BioMed Central Ltd on behalf of the copyright holder
spellingShingle Primary Research
Said, Thenaa K
Moraes, Ricardo CB
Sinha, Raghu
Medina, Daniel
Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
title Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
title_full Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
title_fullStr Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
title_full_unstemmed Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
title_short Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
title_sort mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13923/
https://www.ncbi.nlm.nih.gov/pubmed/11250759
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