Cargando…

Transforming growth factor-β and breast cancer: Lessons learned from genetically altered mouse models

Transforming growth factor (TGF)-βs are plausible candidate tumor suppressors in the breast. They also have oncogenic activities under certain circumstances, however. Genetically altered mouse models provide powerful tools to analyze the complexities of TGF-βaction in the context of the whole animal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wakefield, Lalage M, Yang, Yu-an, Dukhanina, Oksana
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2000
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139431/ https://www.ncbi.nlm.nih.gov/pubmed/11250699 http://dx.doi.org/10.1186/bcr41

Ejemplares similares

Use of mouse models to validate and therapeutically target transforming growth factor beta as an important player in breast cancer progression
por: Wakefield, LM, et al.
Publicado: (2003)

Transforming growth factors-β are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system
por: Zujewski, JoAnne, et al.
Publicado: (2001)

Disruption of Transforming Growth Factor β Signaling by a Novel Ligand-dependent Mechanism
por: Fernandez, Tania, et al.
Publicado: (2002)

An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer
por: Sato, Misako, et al.
Publicado: (2014)

Brightfield Proximity Ligation Assay Reveals Both Canonical and Mixed Transforming Growth Factor-β/Bone Morphogenetic Protein Smad Signaling Complexes in Tissue Sections
por: Flanders, Kathleen C., et al.
Publicado: (2014)

Effective Chemoimmunotherapy with Anti-TGFβ Antibody and Cyclophosphamide in a Mouse Model of Breast Cancer
por: Chen, Xin, et al.
Publicado: (2014)

Transforming growth factor-β and breast cancer: Tumor promoting effects of transforming growth factor-β
por: Dumont, Nancy, et al.
Publicado: (2000)

Delineating Genetic Alterations for Tumor Progression in the MCF10A Series of Breast Cancer Cell Lines
por: Kadota, Mitsutaka, et al.
Publicado: (2010)

Transforming growth factor-β and breast cancer: Transforming growth factor-β/SMAD signaling defects and cancer
por: Kretzschmar, Marcus
Publicado: (2000)

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
por: Chen, Xin, et al.
Publicado: (2014)

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling
por: Wei, Hao, et al.
Publicado: (2017)

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium
por: Flanders, Kathleen C., et al.
Publicado: (2016)

Regulation of Tumor Immune Surveillance and Tumor Immune Subversion by TGF-β
por: Park, Hae-Young, et al.
Publicado: (2009)

Morphomechanical Alterations Induced by Transforming Growth Factor-β1 in Epithelial Breast Cancer Cells
por: Cascione, Mariafrancesca, et al.
Publicado: (2018)

Transforming growth factor-β and breast cancer: Introduction
por: Slingerland, Joyce
Publicado: (2000)

Transforming growth factor-β and breast cancer: Cell cycle arrest by transforming growth factor-β and its disruption in cancer
por: Donovan, Jeffrey, et al.
Publicado: (2000)

SDF-1α Mediates Wound-Promoted Tumor Growth in a Syngeneic Orthotopic Mouse Model of Breast Cancer
por: Stuelten, Christina H., et al.
Publicado: (2013)

Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway
por: Dukhanina, Elena A., et al.
Publicado: (2022)

Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-β Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer
por: Stuelten, Christina H., et al.
Publicado: (2010)

Association between Altered Expression and Genetic Variations of Transforming Growth Factor β-Smad Pathway with Chronic Myeloid Leukemia
por: Shokeen, Yogender, et al.
Publicado: (2018)

Transforming growth factor-β and breast cancer: Mammary gland development
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2000)

Genetic Background May Contribute to PAM50 Gene Expression Breast Cancer Subtype Assignments
por: Hu, Ying, et al.
Publicado: (2013)

Differential Regulation of Mouse B Cell Development by Transforming Growth Factor β1
por: Kaminski, Denise A., et al.
Publicado: (2002)

Differential Proteome Analysis Identifies TGF-β-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model
por: Sato, Misako, et al.
Publicado: (2015)

Transforming growth factor-β in breast cancer: too much, too late
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2009)

Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing
por: Zheng, Zhong, et al.
Publicado: (2014)

HER-2 overexpression differentially alters transforming growth factor-β responses in luminal versus mesenchymal human breast cancer cells
por: Wilson, Cindy A, et al.
Publicado: (2005)

Mouse forestomach carcinoma cells immunosuppress macrophages through transforming growth factor-β1
por: LUO, HUAXING, et al.
Publicado: (2012)

Curcumin Inhibits Transforming Growth Factor β Induced Differentiation of Mouse Lung Fibroblasts to Myofibroblasts
por: Liu, Daishun, et al.
Publicado: (2016)

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis
por: Gao, Yang, et al.
Publicado: (2016)

Genetic dominance of transforming growth factor-β1 polymorphisms in chronic liver disease
por: Cai, Xuanyan, et al.
Publicado: (2022)

Transforming growth factor–β in tissue fibrosis
por: Frangogiannis, Nikolaos G.
Publicado: (2020)

Transforming growth factor-β in tumour development
por: Trelford, Charles B., et al.
Publicado: (2022)

Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor-β (TGF-β) Signaling in Cancer
por: Khin, Sann Sanda, et al.
Publicado: (2011)

Correction: Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing
Publicado: (2021)

Alterations of the Transforming Growth Factor‐(β Signaling Pathway in Hepatocellular Carcinomas Induced Endogenously and Exogenously in Rats
por: Sasaki, Yasutaka, et al.
Publicado: (2001)

Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia
por: Frydecka, Dorota, et al.
Publicado: (2013)

Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells
por: Arase, Mayu, et al.
Publicado: (2014)

Synthesis and secretion of transforming growth factor beta isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen.
por: Benson, J. R., et al.
Publicado: (1996)

Exploring molecular genetics of bladder cancer: lessons learned from mouse models
por: Ahmad, Imran, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9mp2bjda4jpgtholbqsgbbc1j1