Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions

2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.

Detalles Bibliográficos
Autores principales: Babaev, Eugene V, Vasilevich, Natalya I, Ivushkina, Anna S
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2005
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1399457/
https://www.ncbi.nlm.nih.gov/pubmed/16542026
http://dx.doi.org/10.1186/1860-5397-1-9
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author Babaev, Eugene V
Vasilevich, Natalya I
Ivushkina, Anna S
author_facet Babaev, Eugene V
Vasilevich, Natalya I
Ivushkina, Anna S
author_sort Babaev, Eugene V
collection PubMed
description 2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.
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spelling pubmed-13994572006-03-13 Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions Babaev, Eugene V Vasilevich, Natalya I Ivushkina, Anna S Beilstein J Org Chem Preliminary Communication 2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines. Beilstein-Institut 2005-10-07 /pmc/articles/PMC1399457/ /pubmed/16542026 http://dx.doi.org/10.1186/1860-5397-1-9 Text en Copyright © 2005, Babaev et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Babaev, Eugene V
Vasilevich, Natalya I
Ivushkina, Anna S
Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
title Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
title_full Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
title_fullStr Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
title_full_unstemmed Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
title_short Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
title_sort efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1399457/
https://www.ncbi.nlm.nih.gov/pubmed/16542026
http://dx.doi.org/10.1186/1860-5397-1-9
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AT vasilevichnatalyai efficientsynthesisof5substituted2aryl6cyanoindolizinesvianucleophilicsubstitutionreactions
AT ivushkinaannas efficientsynthesisof5substituted2aryl6cyanoindolizinesvianucleophilicsubstitutionreactions

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