Expression of stabilized β-catenin in differentiated neurons of transgenic mice does not result in tumor formation

BACKGROUND: Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling. To determine whether increased Wnt signaling in the adult CNS is sufficient to induce tumor formation, we created transgenic mice expressing either wild-type or activated...

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Detalles Bibliográficos
Autores principales: Kratz, John E, Stearns, Duncan, Huso, David L, Slunt, Hilda H, Price, Donald L, Borchelt, David R, Eberhart, Charles G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139989/
https://www.ncbi.nlm.nih.gov/pubmed/12460454
http://dx.doi.org/10.1186/1471-2407-2-33

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