Methods for direct determination of mitomycin C in aqueous solutions and in urine

Stripping voltammetry (SV) is used to quantitatively determine concentrations of the anti-neoplastic drug mitomycin C (MMC) alone and in mixtures with 5-fluorouracil and cisplatin, both of which are used in combined chemotherapy with MMC. If the accumulation is performed at the potentials of MMC red...

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Detalles Bibliográficos
Autores principales: Marín, Dolores, Pérez, Pedro, Teijeiro, Carmen, Palecek, Emil
Formato: Texto
Lenguaje:English
Publicado: Biological Procedures Online 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140114/
https://www.ncbi.nlm.nih.gov/pubmed/12734598
http://dx.doi.org/10.1251/bpo12
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author Marín, Dolores
Pérez, Pedro
Teijeiro, Carmen
Palecek, Emil
author_facet Marín, Dolores
Pérez, Pedro
Teijeiro, Carmen
Palecek, Emil
author_sort Marín, Dolores
collection PubMed
description Stripping voltammetry (SV) is used to quantitatively determine concentrations of the anti-neoplastic drug mitomycin C (MMC) alone and in mixtures with 5-fluorouracil and cisplatin, both of which are used in combined chemotherapy with MMC. If the accumulation is performed at the potentials of MMC reduction (-0.35 V vs. SCE), reduced MMC is strongly adsorbed at the electrode. It is possible to prepare a MMC-modified electrode, which, after a washing step, is transferred to the background electrolyte to determine MMC by voltammetry. This procedure, which is termed transfer stripping voltammetry (TSV), helps to eliminate interferences and can be applied for a direct determination of MMC alone or in mixtures with other drugs in urine.
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spelling pubmed-1401142006-04-06 Methods for direct determination of mitomycin C in aqueous solutions and in urine Marín, Dolores Pérez, Pedro Teijeiro, Carmen Palecek, Emil Biol Proced Online Research Article Stripping voltammetry (SV) is used to quantitatively determine concentrations of the anti-neoplastic drug mitomycin C (MMC) alone and in mixtures with 5-fluorouracil and cisplatin, both of which are used in combined chemotherapy with MMC. If the accumulation is performed at the potentials of MMC reduction (-0.35 V vs. SCE), reduced MMC is strongly adsorbed at the electrode. It is possible to prepare a MMC-modified electrode, which, after a washing step, is transferred to the background electrolyte to determine MMC by voltammetry. This procedure, which is termed transfer stripping voltammetry (TSV), helps to eliminate interferences and can be applied for a direct determination of MMC alone or in mixtures with other drugs in urine. Biological Procedures Online 1998-09-17 /pmc/articles/PMC140114/ /pubmed/12734598 http://dx.doi.org/10.1251/bpo12 Text en Copyright © September 09, 1998, D Marín et al. Published in Biological Procedures Online under license from the authors. Copying, printing, redistribution and storage permitted.
spellingShingle Research Article
Marín, Dolores
Pérez, Pedro
Teijeiro, Carmen
Palecek, Emil
Methods for direct determination of mitomycin C in aqueous solutions and in urine
title Methods for direct determination of mitomycin C in aqueous solutions and in urine
title_full Methods for direct determination of mitomycin C in aqueous solutions and in urine
title_fullStr Methods for direct determination of mitomycin C in aqueous solutions and in urine
title_full_unstemmed Methods for direct determination of mitomycin C in aqueous solutions and in urine
title_short Methods for direct determination of mitomycin C in aqueous solutions and in urine
title_sort methods for direct determination of mitomycin c in aqueous solutions and in urine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140114/
https://www.ncbi.nlm.nih.gov/pubmed/12734598
http://dx.doi.org/10.1251/bpo12
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AT palecekemil methodsfordirectdeterminationofmitomycincinaqueoussolutionsandinurine

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