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Single nucleotide RNA choreography
New structural analysis methods, and a tree formalism re-define and expand the RNA motif concept, unifying what previously appeared to be disparate groups of structures. We find RNA tetraloops at high frequencies, in new contexts, with unexpected lengths, and in novel topologies. The results, with b...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401506/ https://www.ncbi.nlm.nih.gov/pubmed/16531589 http://dx.doi.org/10.1093/nar/gkj500 |
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author | Hsiao, Chiaolong Mohan, Srividya Hershkovitz, Eli Tannenbaum, Allen Williams, Loren Dean |
author_facet | Hsiao, Chiaolong Mohan, Srividya Hershkovitz, Eli Tannenbaum, Allen Williams, Loren Dean |
author_sort | Hsiao, Chiaolong |
collection | PubMed |
description | New structural analysis methods, and a tree formalism re-define and expand the RNA motif concept, unifying what previously appeared to be disparate groups of structures. We find RNA tetraloops at high frequencies, in new contexts, with unexpected lengths, and in novel topologies. The results, with broad implications for RNA structure in general, show that even at this most elementary level of organization, RNA tolerates astounding variation in conformation, length, sequence and context. However the variation is not random; it is well-described by four distinct modes, which are 3-2 switches (backbone topology variations), insertions, deletions and strand clips. |
format | Text |
id | pubmed-1401506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-14015062006-03-16 Single nucleotide RNA choreography Hsiao, Chiaolong Mohan, Srividya Hershkovitz, Eli Tannenbaum, Allen Williams, Loren Dean Nucleic Acids Res Article New structural analysis methods, and a tree formalism re-define and expand the RNA motif concept, unifying what previously appeared to be disparate groups of structures. We find RNA tetraloops at high frequencies, in new contexts, with unexpected lengths, and in novel topologies. The results, with broad implications for RNA structure in general, show that even at this most elementary level of organization, RNA tolerates astounding variation in conformation, length, sequence and context. However the variation is not random; it is well-described by four distinct modes, which are 3-2 switches (backbone topology variations), insertions, deletions and strand clips. Oxford University Press 2006 2006-03-10 /pmc/articles/PMC1401506/ /pubmed/16531589 http://dx.doi.org/10.1093/nar/gkj500 Text en © The Author 2006. Published by Oxford University Press. All rights reserved |
spellingShingle | Article Hsiao, Chiaolong Mohan, Srividya Hershkovitz, Eli Tannenbaum, Allen Williams, Loren Dean Single nucleotide RNA choreography |
title | Single nucleotide RNA choreography |
title_full | Single nucleotide RNA choreography |
title_fullStr | Single nucleotide RNA choreography |
title_full_unstemmed | Single nucleotide RNA choreography |
title_short | Single nucleotide RNA choreography |
title_sort | single nucleotide rna choreography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401506/ https://www.ncbi.nlm.nih.gov/pubmed/16531589 http://dx.doi.org/10.1093/nar/gkj500 |
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