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Single nucleotide RNA choreography

New structural analysis methods, and a tree formalism re-define and expand the RNA motif concept, unifying what previously appeared to be disparate groups of structures. We find RNA tetraloops at high frequencies, in new contexts, with unexpected lengths, and in novel topologies. The results, with b...

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Detalles Bibliográficos
Autores principales: Hsiao, Chiaolong, Mohan, Srividya, Hershkovitz, Eli, Tannenbaum, Allen, Williams, Loren Dean
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401506/
https://www.ncbi.nlm.nih.gov/pubmed/16531589
http://dx.doi.org/10.1093/nar/gkj500
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author Hsiao, Chiaolong
Mohan, Srividya
Hershkovitz, Eli
Tannenbaum, Allen
Williams, Loren Dean
author_facet Hsiao, Chiaolong
Mohan, Srividya
Hershkovitz, Eli
Tannenbaum, Allen
Williams, Loren Dean
author_sort Hsiao, Chiaolong
collection PubMed
description New structural analysis methods, and a tree formalism re-define and expand the RNA motif concept, unifying what previously appeared to be disparate groups of structures. We find RNA tetraloops at high frequencies, in new contexts, with unexpected lengths, and in novel topologies. The results, with broad implications for RNA structure in general, show that even at this most elementary level of organization, RNA tolerates astounding variation in conformation, length, sequence and context. However the variation is not random; it is well-described by four distinct modes, which are 3-2 switches (backbone topology variations), insertions, deletions and strand clips.
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spelling pubmed-14015062006-03-16 Single nucleotide RNA choreography Hsiao, Chiaolong Mohan, Srividya Hershkovitz, Eli Tannenbaum, Allen Williams, Loren Dean Nucleic Acids Res Article New structural analysis methods, and a tree formalism re-define and expand the RNA motif concept, unifying what previously appeared to be disparate groups of structures. We find RNA tetraloops at high frequencies, in new contexts, with unexpected lengths, and in novel topologies. The results, with broad implications for RNA structure in general, show that even at this most elementary level of organization, RNA tolerates astounding variation in conformation, length, sequence and context. However the variation is not random; it is well-described by four distinct modes, which are 3-2 switches (backbone topology variations), insertions, deletions and strand clips. Oxford University Press 2006 2006-03-10 /pmc/articles/PMC1401506/ /pubmed/16531589 http://dx.doi.org/10.1093/nar/gkj500 Text en © The Author 2006. Published by Oxford University Press. All rights reserved
spellingShingle Article
Hsiao, Chiaolong
Mohan, Srividya
Hershkovitz, Eli
Tannenbaum, Allen
Williams, Loren Dean
Single nucleotide RNA choreography
title Single nucleotide RNA choreography
title_full Single nucleotide RNA choreography
title_fullStr Single nucleotide RNA choreography
title_full_unstemmed Single nucleotide RNA choreography
title_short Single nucleotide RNA choreography
title_sort single nucleotide rna choreography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401506/
https://www.ncbi.nlm.nih.gov/pubmed/16531589
http://dx.doi.org/10.1093/nar/gkj500
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AT williamslorendean singlenucleotidernachoreography