PPAR-γ: a thrifty transcription factor

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-γ as a key player...

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Detalles Bibliográficos
Autores principales: Auwerx, Johan, Cock, Terrie-Ann, Knouff, Chris
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2003
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402226/
https://www.ncbi.nlm.nih.gov/pubmed/16604178
http://dx.doi.org/10.1621/nrs.01006
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author Auwerx, Johan
Cock, Terrie-Ann
Knouff, Chris
author_facet Auwerx, Johan
Cock, Terrie-Ann
Knouff, Chris
author_sort Auwerx, Johan
collection PubMed
description The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-γ as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.
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spelling pubmed-14022262006-04-06 PPAR-γ: a thrifty transcription factor Auwerx, Johan Cock, Terrie-Ann Knouff, Chris Nucl Recept Signal Perspective The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-γ as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes. The Nuclear Receptor Signaling Atlas 2003-06-27 /pmc/articles/PMC1402226/ /pubmed/16604178 http://dx.doi.org/10.1621/nrs.01006 Text en Copyright © 2003, Auwerx et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Auwerx, Johan
Cock, Terrie-Ann
Knouff, Chris
PPAR-γ: a thrifty transcription factor
title PPAR-γ: a thrifty transcription factor
title_full PPAR-γ: a thrifty transcription factor
title_fullStr PPAR-γ: a thrifty transcription factor
title_full_unstemmed PPAR-γ: a thrifty transcription factor
title_short PPAR-γ: a thrifty transcription factor
title_sort ppar-γ: a thrifty transcription factor
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402226/
https://www.ncbi.nlm.nih.gov/pubmed/16604178
http://dx.doi.org/10.1621/nrs.01006
work_keys_str_mv AT auwerxjohan ppargathriftytranscriptionfactor
AT cockterrieann ppargathriftytranscriptionfactor
AT knouffchris ppargathriftytranscriptionfactor

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