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Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration
BACKGROUND: Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as w...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402319/ https://www.ncbi.nlm.nih.gov/pubmed/16430774 http://dx.doi.org/10.1186/1742-6413-3-1 |
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author | Meara, Regina S Reddy, Vishnu Arnoletti, Juan Pablo Jhala, Darshana Varadarajulu, Shyam Jhala, Nirag |
author_facet | Meara, Regina S Reddy, Vishnu Arnoletti, Juan Pablo Jhala, Darshana Varadarajulu, Shyam Jhala, Nirag |
author_sort | Meara, Regina S |
collection | PubMed |
description | BACKGROUND: Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy poses an even greater challenge. Hairy cell leukemia (HCL) is an uncommon, but distinct, lympho-proliferative disorder of B cell origin. It usually affects the spleen and bone marrow and uncommonly involves lymph nodes. There are only a few cases reported where HCL was diagnosed on FNA specimens. CASE PRESENTATION: We report the first case of HCL accurately rendered on EUS-FNA samples. CONCLUSION: This report underscores the concept that the presence of a cytopathologist in the endoscopy suite plays an important role in providing accurate diagnoses of lymphoid lesions biopsied with EUS-FNA. |
format | Text |
id | pubmed-1402319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-14023192006-03-16 Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration Meara, Regina S Reddy, Vishnu Arnoletti, Juan Pablo Jhala, Darshana Varadarajulu, Shyam Jhala, Nirag Cytojournal Research BACKGROUND: Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy poses an even greater challenge. Hairy cell leukemia (HCL) is an uncommon, but distinct, lympho-proliferative disorder of B cell origin. It usually affects the spleen and bone marrow and uncommonly involves lymph nodes. There are only a few cases reported where HCL was diagnosed on FNA specimens. CASE PRESENTATION: We report the first case of HCL accurately rendered on EUS-FNA samples. CONCLUSION: This report underscores the concept that the presence of a cytopathologist in the endoscopy suite plays an important role in providing accurate diagnoses of lymphoid lesions biopsied with EUS-FNA. BioMed Central 2006-01-23 /pmc/articles/PMC1402319/ /pubmed/16430774 http://dx.doi.org/10.1186/1742-6413-3-1 Text en Copyright © 2006 Meara et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Meara, Regina S Reddy, Vishnu Arnoletti, Juan Pablo Jhala, Darshana Varadarajulu, Shyam Jhala, Nirag Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration |
title | Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration |
title_full | Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration |
title_fullStr | Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration |
title_full_unstemmed | Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration |
title_short | Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration |
title_sort | hairy cell leukemia: a diagnosis by endoscopic ultrasound guided fine needle aspiration |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402319/ https://www.ncbi.nlm.nih.gov/pubmed/16430774 http://dx.doi.org/10.1186/1742-6413-3-1 |
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