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Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402327/ https://www.ncbi.nlm.nih.gov/pubmed/16542035 http://dx.doi.org/10.1186/1745-6215-7-2 |
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author | Eftekhar, Behzad Ghodsi, Mohammad Hadadi, Azar Taghipoor, Mousa Sigarchi, Samira Zabihyan Rahimi-Movaghar, Vafa Kazemzadeh, Ehsan Sherafat Esmaeeli, Babak Nejat, Farideh Yalda, Alireza Ketabchi, Ebrahim |
author_facet | Eftekhar, Behzad Ghodsi, Mohammad Hadadi, Azar Taghipoor, Mousa Sigarchi, Samira Zabihyan Rahimi-Movaghar, Vafa Kazemzadeh, Ehsan Sherafat Esmaeeli, Babak Nejat, Farideh Yalda, Alireza Ketabchi, Ebrahim |
author_sort | Eftekhar, Behzad |
collection | PubMed |
description | BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma. CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients. |
format | Text |
id | pubmed-1402327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-14023272006-03-16 Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] Eftekhar, Behzad Ghodsi, Mohammad Hadadi, Azar Taghipoor, Mousa Sigarchi, Samira Zabihyan Rahimi-Movaghar, Vafa Kazemzadeh, Ehsan Sherafat Esmaeeli, Babak Nejat, Farideh Yalda, Alireza Ketabchi, Ebrahim Trials Study Protocol BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma. CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients. BioMed Central 2006-01-18 /pmc/articles/PMC1402327/ /pubmed/16542035 http://dx.doi.org/10.1186/1745-6215-7-2 Text en Copyright © 2006 Eftekhar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study Protocol Eftekhar, Behzad Ghodsi, Mohammad Hadadi, Azar Taghipoor, Mousa Sigarchi, Samira Zabihyan Rahimi-Movaghar, Vafa Kazemzadeh, Ehsan Sherafat Esmaeeli, Babak Nejat, Farideh Yalda, Alireza Ketabchi, Ebrahim Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] |
title | Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] |
title_full | Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] |
title_fullStr | Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] |
title_full_unstemmed | Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] |
title_short | Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] |
title_sort | prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [isrctn71132784] |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402327/ https://www.ncbi.nlm.nih.gov/pubmed/16542035 http://dx.doi.org/10.1186/1745-6215-7-2 |
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