Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]

BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are...

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Autores principales: Eftekhar, Behzad, Ghodsi, Mohammad, Hadadi, Azar, Taghipoor, Mousa, Sigarchi, Samira Zabihyan, Rahimi-Movaghar, Vafa, Kazemzadeh, Ehsan Sherafat, Esmaeeli, Babak, Nejat, Farideh, Yalda, Alireza, Ketabchi, Ebrahim
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402327/
https://www.ncbi.nlm.nih.gov/pubmed/16542035
http://dx.doi.org/10.1186/1745-6215-7-2
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author Eftekhar, Behzad
Ghodsi, Mohammad
Hadadi, Azar
Taghipoor, Mousa
Sigarchi, Samira Zabihyan
Rahimi-Movaghar, Vafa
Kazemzadeh, Ehsan Sherafat
Esmaeeli, Babak
Nejat, Farideh
Yalda, Alireza
Ketabchi, Ebrahim
author_facet Eftekhar, Behzad
Ghodsi, Mohammad
Hadadi, Azar
Taghipoor, Mousa
Sigarchi, Samira Zabihyan
Rahimi-Movaghar, Vafa
Kazemzadeh, Ehsan Sherafat
Esmaeeli, Babak
Nejat, Farideh
Yalda, Alireza
Ketabchi, Ebrahim
author_sort Eftekhar, Behzad
collection PubMed
description BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma. CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.
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spelling pubmed-14023272006-03-16 Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] Eftekhar, Behzad Ghodsi, Mohammad Hadadi, Azar Taghipoor, Mousa Sigarchi, Samira Zabihyan Rahimi-Movaghar, Vafa Kazemzadeh, Ehsan Sherafat Esmaeeli, Babak Nejat, Farideh Yalda, Alireza Ketabchi, Ebrahim Trials Study Protocol BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma. CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients. BioMed Central 2006-01-18 /pmc/articles/PMC1402327/ /pubmed/16542035 http://dx.doi.org/10.1186/1745-6215-7-2 Text en Copyright © 2006 Eftekhar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Eftekhar, Behzad
Ghodsi, Mohammad
Hadadi, Azar
Taghipoor, Mousa
Sigarchi, Samira Zabihyan
Rahimi-Movaghar, Vafa
Kazemzadeh, Ehsan Sherafat
Esmaeeli, Babak
Nejat, Farideh
Yalda, Alireza
Ketabchi, Ebrahim
Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
title Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
title_full Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
title_fullStr Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
title_full_unstemmed Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
title_short Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]
title_sort prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [isrctn71132784]
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402327/
https://www.ncbi.nlm.nih.gov/pubmed/16542035
http://dx.doi.org/10.1186/1745-6215-7-2
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