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JLIN: A java based linkage disequilibrium plotter

BACKGROUND: A great deal of effort and expense are being expended internationally in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Techniques such as Linkage Disequilibrium mapping are being increasingly used to examine and compare markers across i...

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Detalles Bibliográficos
Autores principales: Carter, Kim W, McCaskie, Pamela A, Palmer, Lyle J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402328/
https://www.ncbi.nlm.nih.gov/pubmed/16466584
http://dx.doi.org/10.1186/1471-2105-7-60
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author Carter, Kim W
McCaskie, Pamela A
Palmer, Lyle J
author_facet Carter, Kim W
McCaskie, Pamela A
Palmer, Lyle J
author_sort Carter, Kim W
collection PubMed
description BACKGROUND: A great deal of effort and expense are being expended internationally in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Techniques such as Linkage Disequilibrium mapping are being increasingly used to examine and compare markers across increasingly large datasets. Visualisation techniques are becoming essential to analyse the ever-growing volume of data and results available with any given analysis. RESULTS: JLIN (Java LINkage disequilibrium plotter) is a software package designed for customisable, intuitive visualisation of Linkage Disequilibrium (LD) across all common computing platforms. Customisation allows the user to choose particular visualisations, statistical measures and measurement ranges. JLIN also allows the user to export images of the LD visualisation in several common document formats. CONCLUSION: JLIN allows the user to visually compare and contrast the results of a range of statistical measures on the input dataset(s). These measures include the commonly used D' and r(2 )statistics and empirical p-values. JLIN has a number of unique and novel features that improve on existing LD visualisation tools.
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spelling pubmed-14023282006-03-16 JLIN: A java based linkage disequilibrium plotter Carter, Kim W McCaskie, Pamela A Palmer, Lyle J BMC Bioinformatics Software BACKGROUND: A great deal of effort and expense are being expended internationally in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Techniques such as Linkage Disequilibrium mapping are being increasingly used to examine and compare markers across increasingly large datasets. Visualisation techniques are becoming essential to analyse the ever-growing volume of data and results available with any given analysis. RESULTS: JLIN (Java LINkage disequilibrium plotter) is a software package designed for customisable, intuitive visualisation of Linkage Disequilibrium (LD) across all common computing platforms. Customisation allows the user to choose particular visualisations, statistical measures and measurement ranges. JLIN also allows the user to export images of the LD visualisation in several common document formats. CONCLUSION: JLIN allows the user to visually compare and contrast the results of a range of statistical measures on the input dataset(s). These measures include the commonly used D' and r(2 )statistics and empirical p-values. JLIN has a number of unique and novel features that improve on existing LD visualisation tools. BioMed Central 2006-02-09 /pmc/articles/PMC1402328/ /pubmed/16466584 http://dx.doi.org/10.1186/1471-2105-7-60 Text en Copyright © 2006 Carter et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software
Carter, Kim W
McCaskie, Pamela A
Palmer, Lyle J
JLIN: A java based linkage disequilibrium plotter
title JLIN: A java based linkage disequilibrium plotter
title_full JLIN: A java based linkage disequilibrium plotter
title_fullStr JLIN: A java based linkage disequilibrium plotter
title_full_unstemmed JLIN: A java based linkage disequilibrium plotter
title_short JLIN: A java based linkage disequilibrium plotter
title_sort jlin: a java based linkage disequilibrium plotter
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402328/
https://www.ncbi.nlm.nih.gov/pubmed/16466584
http://dx.doi.org/10.1186/1471-2105-7-60
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