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mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity

Type II Human DNA Topoisomerases (topos II) play an essential role in DNA replication and transcription and are important targets for cancer chemotherapeutic drugs. Topoisomerase II causes transient double-strand breaks in DNA, forming a gate through which another double helix is passed, and acts as...

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Detalles Bibliográficos
Autores principales:	Gilroy, Kathryn L., Leontiou, Chrysoula, Padget, Kay, Lakey, Jeremy H., Austin, Caroline A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405819/ https://www.ncbi.nlm.nih.gov/pubmed/16549872 http://dx.doi.org/10.1093/nar/gkl057

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