Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways

INTRODUCTION: We have previously shown that FTI-277, a farnesyl transferase inhibitor (FTI), enhances the efficacy of tamoxifen (Tam) in inhibiting the proliferation of the estrogen dependent MCF-7 cell line. As the cellular response to Tam is the result of an inhibition of both estrogen receptor-de...

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Detalles Bibliográficos
Autores principales: Dalenc, Florence, Giamarchi, Claire, Petit, Mélissa, Poirot, Marc, Favre, Gilles, Faye, Jean-Charles
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410750/
https://www.ncbi.nlm.nih.gov/pubmed/16457696
http://dx.doi.org/10.1186/bcr1357

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