Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis

INTRODUCTION: The design of clinical trials of interventions aimed at reducing mortality in patients with severe sepsis assumes that the relative treatment effect of the intervention is independent of the patients' risk for death. We reviewed published data from phase III clinical studies of se...

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Detalles Bibliográficos
Autores principales: Macias, William L, Nelson, David R, Williams, Mark, Garg, Rekha, Janes, Jonathan, Sashegyi, Andreas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414006/
https://www.ncbi.nlm.nih.gov/pubmed/16280057
http://dx.doi.org/10.1186/cc3795

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