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Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis
INTRODUCTION: In acute disseminated intravascular coagulation, the effect of antithrombin (AT) administration on elevated levels of D-dimer is not well established. In the present study, we report on changes in circulating levels of D-dimer in response to administration of AT in a series of patients...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414038/ https://www.ncbi.nlm.nih.gov/pubmed/16280058 http://dx.doi.org/10.1186/cc3808 |
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author | Kountchev, Jordan Bijuklic, Klaudija Bellmann, Romuald Wiedermann, Christian J Joannidis, Michael |
author_facet | Kountchev, Jordan Bijuklic, Klaudija Bellmann, Romuald Wiedermann, Christian J Joannidis, Michael |
author_sort | Kountchev, Jordan |
collection | PubMed |
description | INTRODUCTION: In acute disseminated intravascular coagulation, the effect of antithrombin (AT) administration on elevated levels of D-dimer is not well established. In the present study, we report on changes in circulating levels of D-dimer in response to administration of AT in a series of patients with acquired AT deficiency due to severe sepsis. METHODS: Eight consecutive critically ill medical patients presenting with acute disseminated intravascular coagulation associated with severe sepsis/septic shock received a single bolus infusion of AT over 30 minutes, aiming to achieve physiological AT levels. Haemostatic parameters including D-dimer were assessed prior to, 6 and 24 h after AT administration. An average of 42 ± 9 U/kg body weight was infused. RESULTS: Following AT substitution, elevated levels of D-dimer fell whereas AT levels rose. CONCLUSION: These observations support the notion that AT can favourably affect fibrin degradation accompanying disseminated intravascular coagulation of severe sepsis. |
format | Text |
id | pubmed-1414038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-14140382006-03-28 Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis Kountchev, Jordan Bijuklic, Klaudija Bellmann, Romuald Wiedermann, Christian J Joannidis, Michael Crit Care Research INTRODUCTION: In acute disseminated intravascular coagulation, the effect of antithrombin (AT) administration on elevated levels of D-dimer is not well established. In the present study, we report on changes in circulating levels of D-dimer in response to administration of AT in a series of patients with acquired AT deficiency due to severe sepsis. METHODS: Eight consecutive critically ill medical patients presenting with acute disseminated intravascular coagulation associated with severe sepsis/septic shock received a single bolus infusion of AT over 30 minutes, aiming to achieve physiological AT levels. Haemostatic parameters including D-dimer were assessed prior to, 6 and 24 h after AT administration. An average of 42 ± 9 U/kg body weight was infused. RESULTS: Following AT substitution, elevated levels of D-dimer fell whereas AT levels rose. CONCLUSION: These observations support the notion that AT can favourably affect fibrin degradation accompanying disseminated intravascular coagulation of severe sepsis. BioMed Central 2005 2005-09-19 /pmc/articles/PMC1414038/ /pubmed/16280058 http://dx.doi.org/10.1186/cc3808 Text en Copyright © 2005 Kountchev et al.; licensee BioMed Central Ltd. |
spellingShingle | Research Kountchev, Jordan Bijuklic, Klaudija Bellmann, Romuald Wiedermann, Christian J Joannidis, Michael Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
title | Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
title_full | Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
title_fullStr | Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
title_full_unstemmed | Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
title_short | Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
title_sort | reduction of d-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414038/ https://www.ncbi.nlm.nih.gov/pubmed/16280058 http://dx.doi.org/10.1186/cc3808 |
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