Discovery of biological networks from diverse functional genomic data

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally ver...

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Detalles Bibliográficos
Autores principales: Myers, Chad L, Robson, Drew, Wible, Adam, Hibbs, Matthew A, Chiriac, Camelia, Theesfeld, Chandra L, Dolinski, Kara, Troyanskaya, Olga G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414113/
https://www.ncbi.nlm.nih.gov/pubmed/16420673
http://dx.doi.org/10.1186/gb-2005-6-13-r114
Descripción
Sumario:We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.

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