Discovery of biological networks from diverse functional genomic data

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally ver...

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Detalles Bibliográficos
Autores principales: Myers, Chad L, Robson, Drew, Wible, Adam, Hibbs, Matthew A, Chiriac, Camelia, Theesfeld, Chandra L, Dolinski, Kara, Troyanskaya, Olga G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414113/
https://www.ncbi.nlm.nih.gov/pubmed/16420673
http://dx.doi.org/10.1186/gb-2005-6-13-r114
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author Myers, Chad L
Robson, Drew
Wible, Adam
Hibbs, Matthew A
Chiriac, Camelia
Theesfeld, Chandra L
Dolinski, Kara
Troyanskaya, Olga G
author_facet Myers, Chad L
Robson, Drew
Wible, Adam
Hibbs, Matthew A
Chiriac, Camelia
Theesfeld, Chandra L
Dolinski, Kara
Troyanskaya, Olga G
author_sort Myers, Chad L
collection PubMed
description We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.
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spelling pubmed-14141132006-03-28 Discovery of biological networks from diverse functional genomic data Myers, Chad L Robson, Drew Wible, Adam Hibbs, Matthew A Chiriac, Camelia Theesfeld, Chandra L Dolinski, Kara Troyanskaya, Olga G Genome Biol Method We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web. BioMed Central 2005 2005-12-19 /pmc/articles/PMC1414113/ /pubmed/16420673 http://dx.doi.org/10.1186/gb-2005-6-13-r114 Text en Copyright © 2005 Myers et al; licensee BioMed Central Ltd.
spellingShingle Method
Myers, Chad L
Robson, Drew
Wible, Adam
Hibbs, Matthew A
Chiriac, Camelia
Theesfeld, Chandra L
Dolinski, Kara
Troyanskaya, Olga G
Discovery of biological networks from diverse functional genomic data
title Discovery of biological networks from diverse functional genomic data
title_full Discovery of biological networks from diverse functional genomic data
title_fullStr Discovery of biological networks from diverse functional genomic data
title_full_unstemmed Discovery of biological networks from diverse functional genomic data
title_short Discovery of biological networks from diverse functional genomic data
title_sort discovery of biological networks from diverse functional genomic data
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414113/
https://www.ncbi.nlm.nih.gov/pubmed/16420673
http://dx.doi.org/10.1186/gb-2005-6-13-r114
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