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The Cooperative Voltage Sensor Motion that Gates a Potassium Channel
The four arginine-rich S4 helices of a voltage-gated channel move outward through the membrane in response to depolarization, opening and closing gates to generate a transient ionic current. Coupling of voltage sensing to gating was originally thought to operate with the S4s moving independently fro...
Autores principales: | Pathak, Medha, Kurtz, Lisa, Tombola, Francesco, Isacoff, Ehud |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414780/ https://www.ncbi.nlm.nih.gov/pubmed/15623895 http://dx.doi.org/10.1085/jgp.200409197 |
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