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Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752, NCT00260325]

BACKGROUND: Induction of the COX-2 isoenzyme appears to play a major role in the genesis of central sensitization after nociceptive stimulation. This study aimed to investigate the efficacy of a single, oral dose of the specific COX-2 inhibitor-valdecoxib in attenuating the central sensitization – i...

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Detalles Bibliográficos
Autores principales:	Burns, David, Hill, Lindsay, Essandoh, Michael, Jarzembowski, Tomasz M, Schuler, H Gregg, Janicki, Piotr K
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420273/ https://www.ncbi.nlm.nih.gov/pubmed/16529650 http://dx.doi.org/10.1186/1471-2253-6-3

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