Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

BACKGROUND: The cationic lipid Genzyme lipid (GL) 67 is the current "gold-standard" for in vivo lung gene transfer. Here, we assessed, if GL67 mediated uptake of siRNAs and asODNs into airway epithelium in vivo. METHODS: Anti-lacZ and ENaC (epithelial sodium channel) siRNA and asODN were c...

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Detalles Bibliográficos
Autores principales: Griesenbach, Uta, Kitson, Chris, Garcia, Sara Escudero, Farley, Raymond, Singh, Charanjit, Somerton, Luci, Painter, Hazel, Smith, Rbecca L, Gill, Deborah R, Hyde, Stephen C, Chow, Yu-Hua, Hu, Jim, Gray, Mike, Edbrooke, Mark, Ogilvie, Varrie, MacGregor, Gordon, Scheule, Ronald K, Cheng, Seng H, Caplen, Natasha J, Alton, Eric WFW
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420290/
https://www.ncbi.nlm.nih.gov/pubmed/16480492
http://dx.doi.org/10.1186/1465-9921-7-26

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