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Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis

BACKGROUND: Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes. Analysis of mutation spectra of the tumor suppressor that is most commonly mutated in human cancers, p53, unexpectedly suggested that somatic evo...

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Detalles Bibliográficos
Autores principales:	Babenko, Vladimir N, Basu, Malay K, Kondrashov, Fyodor A, Rogozin, Igor B, Koonin, Eugene V
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1431556/ https://www.ncbi.nlm.nih.gov/pubmed/16469093 http://dx.doi.org/10.1186/1471-2407-6-36

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