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Antimicrobial titanium/silver PVD coatings on titanium

BACKGROUND: Biofilm formation and deep infection of endoprostheses is a recurrent complication in implant surgery. Post-operative infections may be overcome by adjusting antimicrobial properties of the implant surface prior to implantation. In this work we described the development of an antimicrobi...

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Detalles Bibliográficos
Autores principales: Ewald, Andrea, Glückermann, Susanne K, Thull, Roger, Gbureck, Uwe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435898/
https://www.ncbi.nlm.nih.gov/pubmed/16556327
http://dx.doi.org/10.1186/1475-925X-5-22
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author Ewald, Andrea
Glückermann, Susanne K
Thull, Roger
Gbureck, Uwe
author_facet Ewald, Andrea
Glückermann, Susanne K
Thull, Roger
Gbureck, Uwe
author_sort Ewald, Andrea
collection PubMed
description BACKGROUND: Biofilm formation and deep infection of endoprostheses is a recurrent complication in implant surgery. Post-operative infections may be overcome by adjusting antimicrobial properties of the implant surface prior to implantation. In this work we described the development of an antimicrobial titanium/silver hard coating via the physical vapor deposition (PVD) process. METHODS: Coatings with a thickness of approximately 2 μm were deposited on titanium surfaces by simultaneous vaporisation of both metals in an inert argon atmosphere with a silver content of approximately 0.7 – 9% as indicated by energy dispersive X-ray analysis. On these surfaces microorganisms and eukaryotic culture cells were grown. RESULTS: The coatings released sufficient silver ions (0.5–2.3 ppb) when immersed in PBS and showed significant antimicrobial potency against Staphylococcus epidermis and Klebsiella pneumoniae strains. At the same time, no cytotoxic effects of the coatings on osteoblast and epithelial cells were found. CONCLUSION: Due to similar mechanical performance when compared to pure titanium, the TiAg coatings should be suitable to provide antimicrobial activity on load-bearing implant surfaces.
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spelling pubmed-14358982006-04-14 Antimicrobial titanium/silver PVD coatings on titanium Ewald, Andrea Glückermann, Susanne K Thull, Roger Gbureck, Uwe Biomed Eng Online Research BACKGROUND: Biofilm formation and deep infection of endoprostheses is a recurrent complication in implant surgery. Post-operative infections may be overcome by adjusting antimicrobial properties of the implant surface prior to implantation. In this work we described the development of an antimicrobial titanium/silver hard coating via the physical vapor deposition (PVD) process. METHODS: Coatings with a thickness of approximately 2 μm were deposited on titanium surfaces by simultaneous vaporisation of both metals in an inert argon atmosphere with a silver content of approximately 0.7 – 9% as indicated by energy dispersive X-ray analysis. On these surfaces microorganisms and eukaryotic culture cells were grown. RESULTS: The coatings released sufficient silver ions (0.5–2.3 ppb) when immersed in PBS and showed significant antimicrobial potency against Staphylococcus epidermis and Klebsiella pneumoniae strains. At the same time, no cytotoxic effects of the coatings on osteoblast and epithelial cells were found. CONCLUSION: Due to similar mechanical performance when compared to pure titanium, the TiAg coatings should be suitable to provide antimicrobial activity on load-bearing implant surfaces. BioMed Central 2006-03-24 /pmc/articles/PMC1435898/ /pubmed/16556327 http://dx.doi.org/10.1186/1475-925X-5-22 Text en Copyright © 2006 Ewald et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ewald, Andrea
Glückermann, Susanne K
Thull, Roger
Gbureck, Uwe
Antimicrobial titanium/silver PVD coatings on titanium
title Antimicrobial titanium/silver PVD coatings on titanium
title_full Antimicrobial titanium/silver PVD coatings on titanium
title_fullStr Antimicrobial titanium/silver PVD coatings on titanium
title_full_unstemmed Antimicrobial titanium/silver PVD coatings on titanium
title_short Antimicrobial titanium/silver PVD coatings on titanium
title_sort antimicrobial titanium/silver pvd coatings on titanium
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435898/
https://www.ncbi.nlm.nih.gov/pubmed/16556327
http://dx.doi.org/10.1186/1475-925X-5-22
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