Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains

BACKGROUND: The cancer-prone and accelerated aging disease Werner syndrome is caused by loss of function of the WRN gene product that possesses ATPase, 3' to 5' helicase and 3' to 5' exonuclease activities. Although WRN has been most prominently suggested to function in telomere...

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Detalles Bibliográficos
Autores principales: Machwe, Amrita, Xiao, Liren, Orren, David K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435914/
https://www.ncbi.nlm.nih.gov/pubmed/16503984
http://dx.doi.org/10.1186/1471-2199-7-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435914/
https://www.ncbi.nlm.nih.gov/pubmed/16503984
http://dx.doi.org/10.1186/1471-2199-7-6

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