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Application of a sensitive collection heuristic for very large protein families: Evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases

BACKGROUND: Manually finding subtle yet statistically significant links to distantly related homologues becomes practically impossible for very populated protein families due to the sheer number of similarity searches to be invoked and analyzed. The unclear evolutionary relationship between classica...

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Detalles Bibliográficos
Autores principales: Schneider, Georg, Neuberger, Georg, Wildpaner, Michael, Tian, Sun, Berezovsky, Igor, Eisenhaber, Frank
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435942/
https://www.ncbi.nlm.nih.gov/pubmed/16551354
http://dx.doi.org/10.1186/1471-2105-7-164