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Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage

Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CL action in the presence of topoisomerase IV from Streptococcus pneumoniae. CL promoted irreversible enzyme-mediated DNA cleavage lead...

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Detalles Bibliográficos
Autores principales:	Richter, Sara N., Leo, Elisabetta, Giaretta, Giulia, Gatto, Barbara, Fisher, L. Mark, Palumbo, Manlio
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435983/ https://www.ncbi.nlm.nih.gov/pubmed/16614448 http://dx.doi.org/10.1093/nar/gkl127

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