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The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET)
BACKGROUND: This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of (18)F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). RESULTS: Tumor-bearing mice (squamous cell carcinoma) maint...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1436004/ https://www.ncbi.nlm.nih.gov/pubmed/16722588 http://dx.doi.org/10.1186/1748-717X-1-3 |
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author | Chan, Linda W Hapdey, Sebastien English, Sean Seidel, Jurgen Carson, Joann Sowers, Anastasia L Krishna, Murali C Green, Michael V Mitchell, James B Bacharach, Stephen L |
author_facet | Chan, Linda W Hapdey, Sebastien English, Sean Seidel, Jurgen Carson, Joann Sowers, Anastasia L Krishna, Murali C Green, Michael V Mitchell, James B Bacharach, Stephen L |
author_sort | Chan, Linda W |
collection | PubMed |
description | BACKGROUND: This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of (18)F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). RESULTS: Tumor-bearing mice (squamous cell carcinoma) maintained at 37°C were studied while breathing either normal air or carbogen (95% O(2), 5% CO(2)), known to significantly oxygenate tumors. Tumor activity was measured within an automatically determined volume of interest (VOI). Activity was corrected for the arterial input function as estimated from image and blood-derived data. Tumor FDG uptake was initially evaluated for tumor-bearing animals breathing only air (2 animals) or only carbogen (2 animals). Subsequently, 5 animals were studied using two sequential (18)F-FDG injections administered to the same tumor-bearing mouse, 60 min apart; the first injection on one gas (air or carbogen) and the second on the other gas. When examining the entire tumor VOI, there was no significant difference of (18)F-FDG uptake between mice breathing either air or carbogen (i.e. air/carbogen ratio near unity). However, when only the highest (18)F-FDG uptake regions of the tumor were considered (small VOIs), there was a modest (21%), but significant increase in the air/carbogen ratio suggesting that in these potentially most hypoxic regions of the tumor, (18)F-FDG uptake and hence glucose metabolism, may be reduced by increasing tumor oxygenation. CONCLUSION: Tumor (18)F-FDG uptake may be reduced by increases in tumor oxygenation and thus may provide a means to further enhance (18)F-FDG functional imaging. |
format | Text |
id | pubmed-1436004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-14360042006-04-18 The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) Chan, Linda W Hapdey, Sebastien English, Sean Seidel, Jurgen Carson, Joann Sowers, Anastasia L Krishna, Murali C Green, Michael V Mitchell, James B Bacharach, Stephen L Radiat Oncol Research BACKGROUND: This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of (18)F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). RESULTS: Tumor-bearing mice (squamous cell carcinoma) maintained at 37°C were studied while breathing either normal air or carbogen (95% O(2), 5% CO(2)), known to significantly oxygenate tumors. Tumor activity was measured within an automatically determined volume of interest (VOI). Activity was corrected for the arterial input function as estimated from image and blood-derived data. Tumor FDG uptake was initially evaluated for tumor-bearing animals breathing only air (2 animals) or only carbogen (2 animals). Subsequently, 5 animals were studied using two sequential (18)F-FDG injections administered to the same tumor-bearing mouse, 60 min apart; the first injection on one gas (air or carbogen) and the second on the other gas. When examining the entire tumor VOI, there was no significant difference of (18)F-FDG uptake between mice breathing either air or carbogen (i.e. air/carbogen ratio near unity). However, when only the highest (18)F-FDG uptake regions of the tumor were considered (small VOIs), there was a modest (21%), but significant increase in the air/carbogen ratio suggesting that in these potentially most hypoxic regions of the tumor, (18)F-FDG uptake and hence glucose metabolism, may be reduced by increasing tumor oxygenation. CONCLUSION: Tumor (18)F-FDG uptake may be reduced by increases in tumor oxygenation and thus may provide a means to further enhance (18)F-FDG functional imaging. BioMed Central 2006-02-28 /pmc/articles/PMC1436004/ /pubmed/16722588 http://dx.doi.org/10.1186/1748-717X-1-3 Text en Copyright © 2006 Chan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Chan, Linda W Hapdey, Sebastien English, Sean Seidel, Jurgen Carson, Joann Sowers, Anastasia L Krishna, Murali C Green, Michael V Mitchell, James B Bacharach, Stephen L The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) |
title | The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) |
title_full | The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) |
title_fullStr | The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) |
title_full_unstemmed | The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) |
title_short | The influence of tumor oxygenation on (18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) |
title_sort | influence of tumor oxygenation on (18)f-fdg (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (pet) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1436004/ https://www.ncbi.nlm.nih.gov/pubmed/16722588 http://dx.doi.org/10.1186/1748-717X-1-3 |
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