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Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life

To determine the influence of endotoxin on the incidence of acute respiratory illness during the first 2 years of life, we carried out a longitudinal follow-up study, beginning at birth, of 332 children born in Prince Edward Island, Canada. We measured 5-day averaged air endotoxin in the homes of ch...

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Autores principales: Dales, Robert, Miller, David, Ruest, Ken, Guay, Mireille, Judek, Stan
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440789/
https://www.ncbi.nlm.nih.gov/pubmed/16581554
http://dx.doi.org/10.1289/ehp.8142
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author Dales, Robert
Miller, David
Ruest, Ken
Guay, Mireille
Judek, Stan
author_facet Dales, Robert
Miller, David
Ruest, Ken
Guay, Mireille
Judek, Stan
author_sort Dales, Robert
collection PubMed
description To determine the influence of endotoxin on the incidence of acute respiratory illness during the first 2 years of life, we carried out a longitudinal follow-up study, beginning at birth, of 332 children born in Prince Edward Island, Canada. We measured 5-day averaged air endotoxin in the homes of children, whose parents provided information by daily symptom diaries and twice-monthly telephone contact for up to 2 years. Endotoxin concentration was 0.49 ± 3.49 EU/m(3) (geometric mean ± geometric SD), and number of annualized illness episodes was 6.83 ± 2.80 (mean ± SD). A doubling of the air endotoxin concentration was associated with an increase of 0.32 illness episodes per year (p = 0.0003), adjusted for age, year of study, breast-feeding, environmental tobacco smoke, child care attendance, indoor temperature, and income. Indoor mold surface area and fungal ergosterol were not significantly associated with endotoxin. Airborne endotoxin appears to be a risk factor for clinically symptomatic respiratory illnesses during the first 2 years of life independent of indoor fungus.
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spelling pubmed-14407892006-05-02 Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life Dales, Robert Miller, David Ruest, Ken Guay, Mireille Judek, Stan Environ Health Perspect Research To determine the influence of endotoxin on the incidence of acute respiratory illness during the first 2 years of life, we carried out a longitudinal follow-up study, beginning at birth, of 332 children born in Prince Edward Island, Canada. We measured 5-day averaged air endotoxin in the homes of children, whose parents provided information by daily symptom diaries and twice-monthly telephone contact for up to 2 years. Endotoxin concentration was 0.49 ± 3.49 EU/m(3) (geometric mean ± geometric SD), and number of annualized illness episodes was 6.83 ± 2.80 (mean ± SD). A doubling of the air endotoxin concentration was associated with an increase of 0.32 illness episodes per year (p = 0.0003), adjusted for age, year of study, breast-feeding, environmental tobacco smoke, child care attendance, indoor temperature, and income. Indoor mold surface area and fungal ergosterol were not significantly associated with endotoxin. Airborne endotoxin appears to be a risk factor for clinically symptomatic respiratory illnesses during the first 2 years of life independent of indoor fungus. National Institute of Environmental Health Sciences 2006-04 2005-11-03 /pmc/articles/PMC1440789/ /pubmed/16581554 http://dx.doi.org/10.1289/ehp.8142 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Dales, Robert
Miller, David
Ruest, Ken
Guay, Mireille
Judek, Stan
Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
title Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
title_full Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
title_fullStr Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
title_full_unstemmed Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
title_short Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
title_sort airborne endotoxin is associated with respiratory illness in the first 2 years of life
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440789/
https://www.ncbi.nlm.nih.gov/pubmed/16581554
http://dx.doi.org/10.1289/ehp.8142
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