Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound

We report here on a chemical genetic screen designed to address the mechanism of action of a small molecule. Small molecules that were active in models of urinary incontinence were tested on the nematode Caenorhabditis elegans, and the resulting phenotypes were used as readouts in a genetic screen t...

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Detalles Bibliográficos
Autores principales: Fitzgerald, Kevin, Tertyshnikova, Svetlana, Moore, Lisa, Bjerke, Lynn, Burley, Ben, Cao, Jian, Carroll, Pamela, Choy, Robert, Doberstein, Steve, Dubaquie, Yves, Franke, Yvonne, Kopczynski, Jenny, Korswagen, Hendrik, Krystek, Stanley R, Lodge, Nicholas J, Plasterk, Ronald, Starrett, John, Stouch, Terry, Thalody, George, Wayne, Honey, van der Linden, Alexander, Zhang, Yongmei, Walker, Stephen G, Cockett, Mark, Wardwell-Swanson, Judi, Ross-Macdonald, Petra, Kindt, Rachel M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440875/
https://www.ncbi.nlm.nih.gov/pubmed/16683034
http://dx.doi.org/10.1371/journal.pgen.0020057

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