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Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia
Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). It has also been implicated in the progression of long-...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448694/ https://www.ncbi.nlm.nih.gov/pubmed/16494646 http://dx.doi.org/10.1111/j.1368-5031.2006.00825.x |
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author | Wright, E Scism-Bacon, JL Glass, LC |
author_facet | Wright, E Scism-Bacon, JL Glass, LC |
author_sort | Wright, E |
collection | PubMed |
description | Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). It has also been implicated in the progression of long-term diabetes complications, including microvascular and macrovascular dysfunction. Excess nourishment and a sedentary lifestyle leads to glucose and fatty acid overload, resulting in production of ROS. Additionally, reaction of glucose with plasma proteins forms advanced glycation end products, triggering production of ROS. These ROS initiate a chain reaction leading to reduced nitric oxide availability, increased markers of inflammation and chemical modification of lipoproteins, all of which may increase the risk of atherogenesis. With the postulation that hyperglycaemia and fluctuations in blood glucose lead to generation of ROS, it follows that aggressive treatment of fasting and postprandial hyperglycaemia is important for prevention of micro and macrovascular complications in T2DM. |
format | Text |
id | pubmed-1448694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-14486942006-05-01 Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia Wright, E Scism-Bacon, JL Glass, LC Int J Clin Pract Review Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). It has also been implicated in the progression of long-term diabetes complications, including microvascular and macrovascular dysfunction. Excess nourishment and a sedentary lifestyle leads to glucose and fatty acid overload, resulting in production of ROS. Additionally, reaction of glucose with plasma proteins forms advanced glycation end products, triggering production of ROS. These ROS initiate a chain reaction leading to reduced nitric oxide availability, increased markers of inflammation and chemical modification of lipoproteins, all of which may increase the risk of atherogenesis. With the postulation that hyperglycaemia and fluctuations in blood glucose lead to generation of ROS, it follows that aggressive treatment of fasting and postprandial hyperglycaemia is important for prevention of micro and macrovascular complications in T2DM. Blackwell Publishing Ltd 2006-03 /pmc/articles/PMC1448694/ /pubmed/16494646 http://dx.doi.org/10.1111/j.1368-5031.2006.00825.x Text en © 2006 The Authors Journal compilation © 2006 Blackwell Publishing Ltd |
spellingShingle | Review Wright, E Scism-Bacon, JL Glass, LC Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
title | Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
title_full | Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
title_fullStr | Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
title_full_unstemmed | Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
title_short | Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
title_sort | oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448694/ https://www.ncbi.nlm.nih.gov/pubmed/16494646 http://dx.doi.org/10.1111/j.1368-5031.2006.00825.x |
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