DNA Methylation Supports Intrinsic Epigenetic Memory in Mammalian Cells

We have investigated the role of DNA methylation in the initiation and maintenance of silenced chromatin in somatic mammalian cells. We found that a mutated transgene, in which all the CpG dinucleotides have been eliminated, underwent transcriptional silencing to the same extent as the unmodified tr...

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Detalles Bibliográficos
Autores principales: Feng, Yong-Qing, Desprat, Romain, Fu, Haiqing, Olivier, Emmanuel, Lin, Chii Mei, Lobell, Amanda, Gowda, Shilpa N, Aladjem, Mirit I, Bouhassira, Eric E
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449906/
https://www.ncbi.nlm.nih.gov/pubmed/16683039
http://dx.doi.org/10.1371/journal.pgen.0020065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449906/
https://www.ncbi.nlm.nih.gov/pubmed/16683039
http://dx.doi.org/10.1371/journal.pgen.0020065

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