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Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype

BACKGROUND: Anaemia is a major cause of morbidity and mortality for children in Africa. The plasma protein haptoglobin (Hp) binds avidly to free haemoglobin released following malaria-induced haemolysis. Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding capacity and diffe...

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Detalles Bibliográficos
Autores principales: Atkinson, Sarah H, Rockett, Kirk, Sirugo, Giorgio, Bejon, Philip A, Fulford, Anthony, O'Connell, Maria A, Bailey, Robin, Kwiatkowski, Dominic P, Prentice, Andrew M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450017/
https://www.ncbi.nlm.nih.gov/pubmed/16637741
http://dx.doi.org/10.1371/journal.pmed.0030172