A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain

The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180° with respect to the active conformation, underlies the specifi...

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Detalles Bibliográficos
Autores principales: Levinson, Nicholas M, Kuchment, Olga, Shen, Kui, Young, Matthew A, Koldobskiy, Michael, Karplus, Martin, Cole, Philip A, Kuriyan, John
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450098/
https://www.ncbi.nlm.nih.gov/pubmed/16640460
http://dx.doi.org/10.1371/journal.pbio.0040144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450098/
https://www.ncbi.nlm.nih.gov/pubmed/16640460
http://dx.doi.org/10.1371/journal.pbio.0040144

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