Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

BACKGROUND: In human breast cancers, amplification of chromosome 11q13 correlates with lymph node metastasis and increased mortality. To date, two genes located within this amplicon, CCND1 and EMS1, were considered to act as oncogenes, because overexpression of both proteins, respectively cyclin D1...

Descripción completa

Detalles Bibliográficos
Autores principales: van Rossum, Agnes GSH, van Bragt, Maaike PA, Schuuring-Scholtes, Ellen, van der Ploeg, Jan CM, van Krieken, Johan HJM, Kluin, Philip M, Schuuring, Ed
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450299/
https://www.ncbi.nlm.nih.gov/pubmed/16536875
http://dx.doi.org/10.1186/1471-2407-6-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450299/
https://www.ncbi.nlm.nih.gov/pubmed/16536875
http://dx.doi.org/10.1186/1471-2407-6-58

Ejemplares similares