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Design of LNA probes that improve mismatch discrimination

Locked nucleic acids (LNA) show remarkable affinity and specificity against native DNA targets. Effects of LNA modifications on mismatch discrimination were studied as a function of sequence context and identity of the mismatch using ultraviolet (UV) melting experiments. A triplet of LNA residues ce...

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Detalles Bibliográficos
Autores principales:	You, Yong, Moreira, Bernardo G., Behlke, Mark A., Owczarzy, Richard
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456327/ https://www.ncbi.nlm.nih.gov/pubmed/16670427 http://dx.doi.org/10.1093/nar/gkl175

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