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CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models

We have previously shown that transgenic mice carrying a mutant human APP but deficient in CD40L, display a decrease in astrocytosis and microgliosis associated with a lower amount of deposited Aβ. Furthermore, an anti-CD40L treatment causes a diminution of Aβ pathology in the brain and an improved...

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Detalles Bibliográficos
Autores principales:	Laporte, Vincent, Ait-Ghezala, Ghania, Volmar, Claude-Henry, Mullan, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456952/ https://www.ncbi.nlm.nih.gov/pubmed/16504112 http://dx.doi.org/10.1186/1742-2094-3-3

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