Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells

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Fapy·dG and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) are formed in DNA by hydroxyl radical damage. In order to study replication past these lesions in cells, we constructed a single-stranded shuttle vector containing the lesion in 5′-TGT and 5′-TGA sequence contexts. Replication of the modifie...

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Detalles Bibliográficos
Autores principales: Kalam, M. Abul, Haraguchi, Kazuhiro, Chandani, Sushil, Loechler, Edward L., Moriya, Maasaki, Greenberg, Marc M., Basu, Ashis K.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458282/
https://www.ncbi.nlm.nih.gov/pubmed/16679449
http://dx.doi.org/10.1093/nar/gkl099

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