Cargando…
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)
Platelet production is induced by the cytokine thrombopoietin (TPO). It is physiologically critical that TPO expression is tightly regulated, because lack of TPO causes life-threatening thrombocytopenia while an excess of TPO results in thrombocytosis. The plasma concentration of TPO is controlled b...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458284/ https://www.ncbi.nlm.nih.gov/pubmed/16679454 http://dx.doi.org/10.1093/nar/gkl277 |