Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

Neutralization of West Nile virus (WNV) in vivo correlates with the development of an antibody response against the viral envelope (E) protein. Using random mutagenesis and yeast surface display, we defined individual contact residues of 14 newly generated monoclonal antibodies against domain III of...

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Detalles Bibliográficos
Autores principales: Oliphant, Theodore, Engle, Michael, Nybakken, Grant E, Doane, Chris, Johnson, Syd, Huang, Ling, Gorlatov, Sergey, Mehlhop, Erin, Marri, Anantha, Chung, Kyung Min, Ebel, Gregory D, Kramer, Laura D, Fremont, Daved H, Diamond, Michael S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458527/
https://www.ncbi.nlm.nih.gov/pubmed/15852016
http://dx.doi.org/10.1038/nm1240

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