Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI

BACKGROUND: A number of gene therapy applications would benefit from vectors capable of expressing multiple genes. In this study we explored the feasibility and efficiency of expressing two or three transgenes in HIV-1 based lentiviral vector. Bicistronic and tricistronic self-inactivating lentivira...

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Detalles Bibliográficos
Autores principales: Chinnasamy, Dhanalakshmi, Milsom, Michael D, Shaffer, James, Neuenfeldt, James, Shaaban, Aimen F, Margison, Geoffrey P, Fairbairn, Leslie J, Chinnasamy, Nachimuthu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459112/
https://www.ncbi.nlm.nih.gov/pubmed/16539700
http://dx.doi.org/10.1186/1743-422X-3-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459112/
https://www.ncbi.nlm.nih.gov/pubmed/16539700
http://dx.doi.org/10.1186/1743-422X-3-14

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