CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain

Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that...

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Detalles Bibliográficos
Autores principales: Ao, Hushan, Ko, Shanelle W, Zhuo, Min
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459854/
https://www.ncbi.nlm.nih.gov/pubmed/16640787
http://dx.doi.org/10.1186/1744-8069-2-15
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author Ao, Hushan
Ko, Shanelle W
Zhuo, Min
author_facet Ao, Hushan
Ko, Shanelle W
Zhuo, Min
author_sort Ao, Hushan
collection PubMed
description Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.
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spelling pubmed-14598542006-05-13 CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain Ao, Hushan Ko, Shanelle W Zhuo, Min Mol Pain Short Report Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain. BioMed Central 2006-04-26 /pmc/articles/PMC1459854/ /pubmed/16640787 http://dx.doi.org/10.1186/1744-8069-2-15 Text en Copyright © 2006 Ao et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Ao, Hushan
Ko, Shanelle W
Zhuo, Min
CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
title CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
title_full CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
title_fullStr CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
title_full_unstemmed CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
title_short CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
title_sort creb activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459854/
https://www.ncbi.nlm.nih.gov/pubmed/16640787
http://dx.doi.org/10.1186/1744-8069-2-15
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AT zhuomin crebactivitymaintainsthesurvivalofcingulatecorticalpyramidalneuronsintheadultmousebrain

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