Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study

BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart diseas...

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Autores principales: Kessel, Line, Jørgensen, Torben, Glümer, Charlotte, Larsen, Michael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459876/
https://www.ncbi.nlm.nih.gov/pubmed/16618373
http://dx.doi.org/10.1186/1471-2415-6-16
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author Kessel, Line
Jørgensen, Torben
Glümer, Charlotte
Larsen, Michael
author_facet Kessel, Line
Jørgensen, Torben
Glümer, Charlotte
Larsen, Michael
author_sort Kessel, Line
collection PubMed
description BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging. METHODS: A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard (® )software. Lens aging was quantified by lens fluorometry. RESULTS: The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia. CONCLUSION: The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.
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spelling pubmed-14598762006-05-13 Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study Kessel, Line Jørgensen, Torben Glümer, Charlotte Larsen, Michael BMC Ophthalmol Research Article BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging. METHODS: A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard (® )software. Lens aging was quantified by lens fluorometry. RESULTS: The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia. CONCLUSION: The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage. BioMed Central 2006-04-18 /pmc/articles/PMC1459876/ /pubmed/16618373 http://dx.doi.org/10.1186/1471-2415-6-16 Text en Copyright © 2006 Kessel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kessel, Line
Jørgensen, Torben
Glümer, Charlotte
Larsen, Michael
Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
title Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
title_full Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
title_fullStr Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
title_full_unstemmed Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
title_short Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
title_sort early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459876/
https://www.ncbi.nlm.nih.gov/pubmed/16618373
http://dx.doi.org/10.1186/1471-2415-6-16
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