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Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats
Exposure of pregnant Long-Evans rats to elemental mercury (Hg(0)) vapor resulted in a significant accumulation of Hg in tissues of neonates. Because elevated Hg in neonatal tissues may adversely affect growth and development, we were interested in how rapidly Hg was eliminated from neonatal tissues....
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459928/ https://www.ncbi.nlm.nih.gov/pubmed/16675429 http://dx.doi.org/10.1289/ehp.8754 |
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author | Morgan, Daniel L. Price, Herman C. Fernando, Reshan Chanda, Sushmita M. O’Connor, Robert W. Barone, Stanley S. Herr, David W. Beliles, Robert P. |
author_facet | Morgan, Daniel L. Price, Herman C. Fernando, Reshan Chanda, Sushmita M. O’Connor, Robert W. Barone, Stanley S. Herr, David W. Beliles, Robert P. |
author_sort | Morgan, Daniel L. |
collection | PubMed |
description | Exposure of pregnant Long-Evans rats to elemental mercury (Hg(0)) vapor resulted in a significant accumulation of Hg in tissues of neonates. Because elevated Hg in neonatal tissues may adversely affect growth and development, we were interested in how rapidly Hg was eliminated from neonatal tissues. Pregnant rats were exposed to 1, 2, or 4 mg Hg(0) vapor/m(3) or air (controls) for 2 hr/day from gestation day 6 (GD6) through GD15. Neonatal brain, liver, and kidney were analyzed for total Hg at various times between birth and postnatal day 90 (PND90). Milk was analyzed for Hg between birth and weaning (PND21). Before weaning, the Hg levels in neonatal tissues were proportional to maternal exposure concentrations and were highest in kidney followed by liver and then brain. There was no elimination of Hg between birth and weaning, indicating that neonates were exposed continuously to elevated levels of Hg during postpartum growth and development. Consumption of milk from exposed dams resulted in a slight increase in kidney Hg concentration during this period. Unexpectedly, neonatal Hg accumulation increased rapidly after weaning. Increased Hg was measured in both control and exposed neonates and was attributed to consumption of NIH-07 diet containing trace levels of Hg. By PND90, tissue Hg levels equilibrated at concentrations similar to those in unexposed adult Long-Evans rats fed the same diet. These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg(0) vapor. |
format | Text |
id | pubmed-1459928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-14599282006-05-23 Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats Morgan, Daniel L. Price, Herman C. Fernando, Reshan Chanda, Sushmita M. O’Connor, Robert W. Barone, Stanley S. Herr, David W. Beliles, Robert P. Environ Health Perspect Research Exposure of pregnant Long-Evans rats to elemental mercury (Hg(0)) vapor resulted in a significant accumulation of Hg in tissues of neonates. Because elevated Hg in neonatal tissues may adversely affect growth and development, we were interested in how rapidly Hg was eliminated from neonatal tissues. Pregnant rats were exposed to 1, 2, or 4 mg Hg(0) vapor/m(3) or air (controls) for 2 hr/day from gestation day 6 (GD6) through GD15. Neonatal brain, liver, and kidney were analyzed for total Hg at various times between birth and postnatal day 90 (PND90). Milk was analyzed for Hg between birth and weaning (PND21). Before weaning, the Hg levels in neonatal tissues were proportional to maternal exposure concentrations and were highest in kidney followed by liver and then brain. There was no elimination of Hg between birth and weaning, indicating that neonates were exposed continuously to elevated levels of Hg during postpartum growth and development. Consumption of milk from exposed dams resulted in a slight increase in kidney Hg concentration during this period. Unexpectedly, neonatal Hg accumulation increased rapidly after weaning. Increased Hg was measured in both control and exposed neonates and was attributed to consumption of NIH-07 diet containing trace levels of Hg. By PND90, tissue Hg levels equilibrated at concentrations similar to those in unexposed adult Long-Evans rats fed the same diet. These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg(0) vapor. National Institute of Environmental Health Sciences 2006-05 2006-01-13 /pmc/articles/PMC1459928/ /pubmed/16675429 http://dx.doi.org/10.1289/ehp.8754 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Morgan, Daniel L. Price, Herman C. Fernando, Reshan Chanda, Sushmita M. O’Connor, Robert W. Barone, Stanley S. Herr, David W. Beliles, Robert P. Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats |
title | Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats |
title_full | Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats |
title_fullStr | Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats |
title_full_unstemmed | Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats |
title_short | Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats |
title_sort | gestational mercury vapor exposure and diet contribute to mercury accumulation in neonatal rats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459928/ https://www.ncbi.nlm.nih.gov/pubmed/16675429 http://dx.doi.org/10.1289/ehp.8754 |
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