Lentiviral Expression of Retinal Guanylate Cyclase-1 (RetGC1) Restores Vision in an Avian Model of Childhood Blindness

BACKGROUND: Leber congenital amaurosis (LCA) is a genetically heterogeneous group of retinal diseases that cause congenital blindness in infants and children. Mutations in the GUCY2D gene that encodes retinal guanylate cyclase–1 (retGC1) were the first to be linked to this disease group (LCA type 1...

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Detalles Bibliográficos
Autores principales: Williams, Melissa L, Coleman, Jason E, Haire, Shannon E, Aleman, Tomas S, Cideciyan, Artur V, Sokal, Izabel, Palczewski, Krzysztof, Jacobson, Samuel G, Semple-Rowland, Susan L
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463903/
https://www.ncbi.nlm.nih.gov/pubmed/16700630
http://dx.doi.org/10.1371/journal.pmed.0030201

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