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Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation

BACKGROUND: Thrombospondins (TSPs) are evolutionarily-conserved, extracellular, calcium-binding glycoproteins with important roles in cell-extracellular matrix interactions, angiogenesis, synaptogenesis and connective tissue organisation. Five TSPs, designated TSP-1 through TSP-5, are encoded in the...

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Detalles Bibliográficos
Autores principales: McKenzie, Patrick, Chadalavada, Seetharam C, Bohrer, Justin, Adams, Josephine C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464143/
https://www.ncbi.nlm.nih.gov/pubmed/16620379
http://dx.doi.org/10.1186/1471-2148-6-33