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Idiopathic chronic eosinophilic pneumonia

Idiopathic chronic eosinophilic pneumonia (ICEP) is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm(3). In absence of...

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Autores principales: Marchand, Eric, Cordier, Jean-François
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464381/
https://www.ncbi.nlm.nih.gov/pubmed/16722612
http://dx.doi.org/10.1186/1750-1172-1-11
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author Marchand, Eric
Cordier, Jean-François
author_facet Marchand, Eric
Cordier, Jean-François
author_sort Marchand, Eric
collection PubMed
description Idiopathic chronic eosinophilic pneumonia (ICEP) is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm(3). In absence of significant blood eosinophilia, a diagnosis of ICEP is supported by the demonstration of bronchoalveolar lavage eosinophilia. ICEP is typically associated with eosinophil counts higher than lymphocyte counts in the bronchoalveolar lavage. ICEP is a rare disorder of unknown cause. Its exact prevalence remains unknown. ICEP may affect every age group but is rare in childhood. It is twice as frequent in women as in men. One third to one half of the ICEP patients have a history of asthma. The mainstay of treatment of ICEP is systemic corticosteroids. Response to oral corticosteroid therapy is dramatic and has led to the consideration of corticosteroid challenge as a diagnostic test for ICEP. Nevertheless, relapses or development of severe asthma are frequent when tapering or withdrawing treatment. Long-term oral corticosteroid therapy is necessary in up to half of the patients.
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spelling pubmed-14643812006-05-23 Idiopathic chronic eosinophilic pneumonia Marchand, Eric Cordier, Jean-François Orphanet J Rare Dis Review Idiopathic chronic eosinophilic pneumonia (ICEP) is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm(3). In absence of significant blood eosinophilia, a diagnosis of ICEP is supported by the demonstration of bronchoalveolar lavage eosinophilia. ICEP is typically associated with eosinophil counts higher than lymphocyte counts in the bronchoalveolar lavage. ICEP is a rare disorder of unknown cause. Its exact prevalence remains unknown. ICEP may affect every age group but is rare in childhood. It is twice as frequent in women as in men. One third to one half of the ICEP patients have a history of asthma. The mainstay of treatment of ICEP is systemic corticosteroids. Response to oral corticosteroid therapy is dramatic and has led to the consideration of corticosteroid challenge as a diagnostic test for ICEP. Nevertheless, relapses or development of severe asthma are frequent when tapering or withdrawing treatment. Long-term oral corticosteroid therapy is necessary in up to half of the patients. BioMed Central 2006-04-06 /pmc/articles/PMC1464381/ /pubmed/16722612 http://dx.doi.org/10.1186/1750-1172-1-11 Text en Copyright © 2006 Marchand and Cordier; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Marchand, Eric
Cordier, Jean-François
Idiopathic chronic eosinophilic pneumonia
title Idiopathic chronic eosinophilic pneumonia
title_full Idiopathic chronic eosinophilic pneumonia
title_fullStr Idiopathic chronic eosinophilic pneumonia
title_full_unstemmed Idiopathic chronic eosinophilic pneumonia
title_short Idiopathic chronic eosinophilic pneumonia
title_sort idiopathic chronic eosinophilic pneumonia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464381/
https://www.ncbi.nlm.nih.gov/pubmed/16722612
http://dx.doi.org/10.1186/1750-1172-1-11
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