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Post-stenotic aortic dilatation

Aortic stenosis is the most common valvular heart disease affecting up to 4% of the elderly population. It can be associated with dilatation of the ascending aorta and subsequent dissection. Post-stenotic dilatation is seen in patients with AS and/or aortic regurgitation, patients with a haemodynami...

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Detalles Bibliográficos
Autores principales: Wilton, Emma, Jahangiri, Marjan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464384/
https://www.ncbi.nlm.nih.gov/pubmed/16722611
http://dx.doi.org/10.1186/1749-8090-1-7
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author Wilton, Emma
Jahangiri, Marjan
author_facet Wilton, Emma
Jahangiri, Marjan
author_sort Wilton, Emma
collection PubMed
description Aortic stenosis is the most common valvular heart disease affecting up to 4% of the elderly population. It can be associated with dilatation of the ascending aorta and subsequent dissection. Post-stenotic dilatation is seen in patients with AS and/or aortic regurgitation, patients with a haemodynamically normal bicuspid aortic valve and following aortic valve replacement. Controversy exists as to whether to replace the aortic root and ascending aorta at the time of aortic valve replacement, an operation that potentially carries a higher morbidity and mortality. The aetiology of post-stenotic aortic dilatation remains controversial. It may be due to haemodynamic factors caused by a stenotic valve, involving high velocity and turbulent flow downstream of the stenosis, or due to intrinsic pathology of the aortic wall. This may involve an abnormality in the process of extracellular matrix remodelling in the aortic wall including inadequate synthesis, degradation and transport of extracellular matrix proteins. This article reviews the aetiology, pathology and management of patients with post-stenotic aortic dilatation.
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spelling pubmed-14643842006-05-23 Post-stenotic aortic dilatation Wilton, Emma Jahangiri, Marjan J Cardiothorac Surg Review Aortic stenosis is the most common valvular heart disease affecting up to 4% of the elderly population. It can be associated with dilatation of the ascending aorta and subsequent dissection. Post-stenotic dilatation is seen in patients with AS and/or aortic regurgitation, patients with a haemodynamically normal bicuspid aortic valve and following aortic valve replacement. Controversy exists as to whether to replace the aortic root and ascending aorta at the time of aortic valve replacement, an operation that potentially carries a higher morbidity and mortality. The aetiology of post-stenotic aortic dilatation remains controversial. It may be due to haemodynamic factors caused by a stenotic valve, involving high velocity and turbulent flow downstream of the stenosis, or due to intrinsic pathology of the aortic wall. This may involve an abnormality in the process of extracellular matrix remodelling in the aortic wall including inadequate synthesis, degradation and transport of extracellular matrix proteins. This article reviews the aetiology, pathology and management of patients with post-stenotic aortic dilatation. BioMed Central 2006-03-03 /pmc/articles/PMC1464384/ /pubmed/16722611 http://dx.doi.org/10.1186/1749-8090-1-7 Text en Copyright © 2006 Wilton and Jahangiri; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wilton, Emma
Jahangiri, Marjan
Post-stenotic aortic dilatation
title Post-stenotic aortic dilatation
title_full Post-stenotic aortic dilatation
title_fullStr Post-stenotic aortic dilatation
title_full_unstemmed Post-stenotic aortic dilatation
title_short Post-stenotic aortic dilatation
title_sort post-stenotic aortic dilatation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464384/
https://www.ncbi.nlm.nih.gov/pubmed/16722611
http://dx.doi.org/10.1186/1749-8090-1-7
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