Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.

By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete...

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Detalles Bibliográficos
Autores principales: Tan, W Y, Zhang, J H
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469439/
https://www.ncbi.nlm.nih.gov/pubmed/8875162
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author Tan, W Y
Zhang, J H
author_facet Tan, W Y
Zhang, J H
author_sort Tan, W Y
collection PubMed
description By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. As expected, the 3-poly test is insensitive to the toxicity of many agents.
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spelling pubmed-14694392006-06-01 Monte Carlo results for the 3-poly test for animal carcinogenicity experiments. Tan, W Y Zhang, J H Environ Health Perspect Research Article By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. As expected, the 3-poly test is insensitive to the toxicity of many agents. 1996-08 /pmc/articles/PMC1469439/ /pubmed/8875162 Text en
spellingShingle Research Article
Tan, W Y
Zhang, J H
Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.
title Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.
title_full Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.
title_fullStr Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.
title_full_unstemmed Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.
title_short Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.
title_sort monte carlo results for the 3-poly test for animal carcinogenicity experiments.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469439/
https://www.ncbi.nlm.nih.gov/pubmed/8875162
work_keys_str_mv AT tanwy montecarloresultsforthe3polytestforanimalcarcinogenicityexperiments
AT zhangjh montecarloresultsforthe3polytestforanimalcarcinogenicityexperiments

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