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Pulmonary reactions to organic dust exposures: development of an animal model.
Acute inhalation of organic dusts such as cotton, hay, silage, grain, animal confinement, or compost dust can result in illness characterized by fever, pulmonary inflammation, chest tightness, and airway obstruction. These agricultural materials are complex mixtures of plant, bacterial, and fungal p...
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1996
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469574/ https://www.ncbi.nlm.nih.gov/pubmed/8722109 |
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author | Castranova, V Robinson, V A Frazer, D G |
author_facet | Castranova, V Robinson, V A Frazer, D G |
author_sort | Castranova, V |
collection | PubMed |
description | Acute inhalation of organic dusts such as cotton, hay, silage, grain, animal confinement, or compost dust can result in illness characterized by fever, pulmonary inflammation, chest tightness, and airway obstruction. These agricultural materials are complex mixtures of plant, bacterial, and fungal products. Elucidation of the time course of disease onset, the mechanisms of disease progression, and the identity of etiologic agents is essential for effective prevention and treatment. Toward this end, animal models for acute organic dust-induced reactions have been developed and characterized. Information concerning the applicability of various animal models to humans and progress toward elucidation of causative agents and mechanisms of action is presented. |
format | Text |
id | pubmed-1469574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
record_format | MEDLINE/PubMed |
spelling | pubmed-14695742006-06-01 Pulmonary reactions to organic dust exposures: development of an animal model. Castranova, V Robinson, V A Frazer, D G Environ Health Perspect Research Article Acute inhalation of organic dusts such as cotton, hay, silage, grain, animal confinement, or compost dust can result in illness characterized by fever, pulmonary inflammation, chest tightness, and airway obstruction. These agricultural materials are complex mixtures of plant, bacterial, and fungal products. Elucidation of the time course of disease onset, the mechanisms of disease progression, and the identity of etiologic agents is essential for effective prevention and treatment. Toward this end, animal models for acute organic dust-induced reactions have been developed and characterized. Information concerning the applicability of various animal models to humans and progress toward elucidation of causative agents and mechanisms of action is presented. 1996-03 /pmc/articles/PMC1469574/ /pubmed/8722109 Text en |
spellingShingle | Research Article Castranova, V Robinson, V A Frazer, D G Pulmonary reactions to organic dust exposures: development of an animal model. |
title | Pulmonary reactions to organic dust exposures: development of an animal model. |
title_full | Pulmonary reactions to organic dust exposures: development of an animal model. |
title_fullStr | Pulmonary reactions to organic dust exposures: development of an animal model. |
title_full_unstemmed | Pulmonary reactions to organic dust exposures: development of an animal model. |
title_short | Pulmonary reactions to organic dust exposures: development of an animal model. |
title_sort | pulmonary reactions to organic dust exposures: development of an animal model. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469574/ https://www.ncbi.nlm.nih.gov/pubmed/8722109 |
work_keys_str_mv | AT castranovav pulmonaryreactionstoorganicdustexposuresdevelopmentofananimalmodel AT robinsonva pulmonaryreactionstoorganicdustexposuresdevelopmentofananimalmodel AT frazerdg pulmonaryreactionstoorganicdustexposuresdevelopmentofananimalmodel |