Neurobehavioral aspects of developmental toxicity testing.

Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become dee...

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Detalles Bibliográficos
Autores principales: Ulbrich, B, Palmer, A K
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469579/
https://www.ncbi.nlm.nih.gov/pubmed/9182049
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author Ulbrich, B
Palmer, A K
author_facet Ulbrich, B
Palmer, A K
author_sort Ulbrich, B
collection PubMed
description Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of animal species and data evaluation. Other problematic areas of study design and conduct, selection of litter representatives for testing, what methods to combine in a testing battery, and statistical treatment of results and their interpretation, will need more research and discussion in the future.
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spelling pubmed-14695792006-06-01 Neurobehavioral aspects of developmental toxicity testing. Ulbrich, B Palmer, A K Environ Health Perspect Research Article Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of animal species and data evaluation. Other problematic areas of study design and conduct, selection of litter representatives for testing, what methods to combine in a testing battery, and statistical treatment of results and their interpretation, will need more research and discussion in the future. 1996-04 /pmc/articles/PMC1469579/ /pubmed/9182049 Text en
spellingShingle Research Article
Ulbrich, B
Palmer, A K
Neurobehavioral aspects of developmental toxicity testing.
title Neurobehavioral aspects of developmental toxicity testing.
title_full Neurobehavioral aspects of developmental toxicity testing.
title_fullStr Neurobehavioral aspects of developmental toxicity testing.
title_full_unstemmed Neurobehavioral aspects of developmental toxicity testing.
title_short Neurobehavioral aspects of developmental toxicity testing.
title_sort neurobehavioral aspects of developmental toxicity testing.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469579/
https://www.ncbi.nlm.nih.gov/pubmed/9182049
work_keys_str_mv AT ulbrichb neurobehavioralaspectsofdevelopmentaltoxicitytesting
AT palmerak neurobehavioralaspectsofdevelopmentaltoxicitytesting

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