Cargando…

Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.

The ability to identify potential neurotoxicants depends upon the characteristics of our test instruments. The neurotoxic properties of lead, methylmercury, polychlorinated biphenyls, and organic solvents would all have been detected at some dose level by tests in current use, provided that the dose...

Descripción completa

Detalles Bibliográficos
Autores principales: Rice, D C, Evangelista de Duffard, A M, Duffard, R, Iregren, A, Satoh, H, Watanabe, C
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469598/
https://www.ncbi.nlm.nih.gov/pubmed/8860323
_version_ 1782127644228190208
author Rice, D C
Evangelista de Duffard, A M
Duffard, R
Iregren, A
Satoh, H
Watanabe, C
author_facet Rice, D C
Evangelista de Duffard, A M
Duffard, R
Iregren, A
Satoh, H
Watanabe, C
author_sort Rice, D C
collection PubMed
description The ability to identify potential neurotoxicants depends upon the characteristics of our test instruments. The neurotoxic properties of lead, methylmercury, polychlorinated biphenyls, and organic solvents would all have been detected at some dose level by tests in current use, provided that the doses were high enough and administered at an appropriate time such as during gestation. The adequacy of animal studies, particularly rodent studies, to predict intake levels at which human health can be protected is disappointing, however. It is unlikely that the use of advanced behavioral methodology would alleviate the apparent lack of sensitivity of the rodent model for many agents.
format Text
id pubmed-1469598
institution National Center for Biotechnology Information
language English
publishDate 1996
record_format MEDLINE/PubMed
spelling pubmed-14695982006-06-01 Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report. Rice, D C Evangelista de Duffard, A M Duffard, R Iregren, A Satoh, H Watanabe, C Environ Health Perspect Research Article The ability to identify potential neurotoxicants depends upon the characteristics of our test instruments. The neurotoxic properties of lead, methylmercury, polychlorinated biphenyls, and organic solvents would all have been detected at some dose level by tests in current use, provided that the doses were high enough and administered at an appropriate time such as during gestation. The adequacy of animal studies, particularly rodent studies, to predict intake levels at which human health can be protected is disappointing, however. It is unlikely that the use of advanced behavioral methodology would alleviate the apparent lack of sensitivity of the rodent model for many agents. 1996-04 /pmc/articles/PMC1469598/ /pubmed/8860323 Text en
spellingShingle Research Article
Rice, D C
Evangelista de Duffard, A M
Duffard, R
Iregren, A
Satoh, H
Watanabe, C
Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
title Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
title_full Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
title_fullStr Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
title_full_unstemmed Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
title_short Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
title_sort lessons for neurotoxicology from selected model compounds: sgomsec joint report.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469598/
https://www.ncbi.nlm.nih.gov/pubmed/8860323
work_keys_str_mv AT ricedc lessonsforneurotoxicologyfromselectedmodelcompoundssgomsecjointreport
AT evangelistadeduffardam lessonsforneurotoxicologyfromselectedmodelcompoundssgomsecjointreport
AT duffardr lessonsforneurotoxicologyfromselectedmodelcompoundssgomsecjointreport
AT iregrena lessonsforneurotoxicologyfromselectedmodelcompoundssgomsecjointreport
AT satohh lessonsforneurotoxicologyfromselectedmodelcompoundssgomsecjointreport
AT watanabec lessonsforneurotoxicologyfromselectedmodelcompoundssgomsecjointreport