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Biological monitoring of workers exposed to emissions from petroleum plants.

This paper presents some of the results from the Commission of the European Communities collaborative research program (contract number EV5V-CT92-0221), whose aim is to investigate the relationship between exposure to petroleum emissions, benzene, and induction of genetic damage in human cells. Twen...

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Detalles Bibliográficos
Autores principales: Anderson, D, Hughes, J A, Cebulska-Wasilewska, A, Wierzewska, A, Kasper, E
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469663/
https://www.ncbi.nlm.nih.gov/pubmed/8781391
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author Anderson, D
Hughes, J A
Cebulska-Wasilewska, A
Wierzewska, A
Kasper, E
author_facet Anderson, D
Hughes, J A
Cebulska-Wasilewska, A
Wierzewska, A
Kasper, E
author_sort Anderson, D
collection PubMed
description This paper presents some of the results from the Commission of the European Communities collaborative research program (contract number EV5V-CT92-0221), whose aim is to investigate the relationship between exposure to petroleum emissions, benzene, and induction of genetic damage in human cells. Twenty-four workers from petroleum plants in Poland and 35 unexposed controls were examined for cytogenetic effects and ras oncoprotein levels and their relationship to confounding factors (e.g., smoking habit, sex family cancer history, and seasonal influence). Preliminary data of chromosome aberrations (CA) and sister chromatid exchanges (SCE) showed differences among sampling subgroups. In this present study, the levels of ras p21 proteins were determined and further analyses of CA, SCE, high frequency cells (HFC), and proliferative rate index (PRI) have been undertaken. Results show that the exposed group has statistically significant increases in CA, and percent of aberrant cells. There were no differences between exposed and unexposed groups in SCE, HFC, PRI, or the levels of ras p21 proteins. Smoking was found to statistically significantly affect levels of CA, percent of aberrant cells, SCE, HFC, and ras proteins. Sister chromatid exchanges were also statistically significantly sex dependent (7.5 breaks/cells for females and 6.8 breaks/cell for males). There were no statistically significant differences for CA, percent aberrant cells, SCE, HFC, or ras p21 protein levels in subgroups characterized according to cancer cases reported in the immediate family. A seasonal variability was shown with statistically significant increases in various biomarkers in the winter. Unexposed groups also showed increases due to smoking and season. The nonsmoking group individuals also showed statistically significant increases in cytogenetic damage with exposure.
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spelling pubmed-14696632006-06-01 Biological monitoring of workers exposed to emissions from petroleum plants. Anderson, D Hughes, J A Cebulska-Wasilewska, A Wierzewska, A Kasper, E Environ Health Perspect Research Article This paper presents some of the results from the Commission of the European Communities collaborative research program (contract number EV5V-CT92-0221), whose aim is to investigate the relationship between exposure to petroleum emissions, benzene, and induction of genetic damage in human cells. Twenty-four workers from petroleum plants in Poland and 35 unexposed controls were examined for cytogenetic effects and ras oncoprotein levels and their relationship to confounding factors (e.g., smoking habit, sex family cancer history, and seasonal influence). Preliminary data of chromosome aberrations (CA) and sister chromatid exchanges (SCE) showed differences among sampling subgroups. In this present study, the levels of ras p21 proteins were determined and further analyses of CA, SCE, high frequency cells (HFC), and proliferative rate index (PRI) have been undertaken. Results show that the exposed group has statistically significant increases in CA, and percent of aberrant cells. There were no differences between exposed and unexposed groups in SCE, HFC, PRI, or the levels of ras p21 proteins. Smoking was found to statistically significantly affect levels of CA, percent of aberrant cells, SCE, HFC, and ras proteins. Sister chromatid exchanges were also statistically significantly sex dependent (7.5 breaks/cells for females and 6.8 breaks/cell for males). There were no statistically significant differences for CA, percent aberrant cells, SCE, HFC, or ras p21 protein levels in subgroups characterized according to cancer cases reported in the immediate family. A seasonal variability was shown with statistically significant increases in various biomarkers in the winter. Unexposed groups also showed increases due to smoking and season. The nonsmoking group individuals also showed statistically significant increases in cytogenetic damage with exposure. 1996-05 /pmc/articles/PMC1469663/ /pubmed/8781391 Text en
spellingShingle Research Article
Anderson, D
Hughes, J A
Cebulska-Wasilewska, A
Wierzewska, A
Kasper, E
Biological monitoring of workers exposed to emissions from petroleum plants.
title Biological monitoring of workers exposed to emissions from petroleum plants.
title_full Biological monitoring of workers exposed to emissions from petroleum plants.
title_fullStr Biological monitoring of workers exposed to emissions from petroleum plants.
title_full_unstemmed Biological monitoring of workers exposed to emissions from petroleum plants.
title_short Biological monitoring of workers exposed to emissions from petroleum plants.
title_sort biological monitoring of workers exposed to emissions from petroleum plants.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469663/
https://www.ncbi.nlm.nih.gov/pubmed/8781391
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